منابع مشابه
Regulation of the nuclear poly(A)-binding protein by arginine methylation in fission yeast.
Two structurally different poly(A)-binding proteins (PABP) bind the poly(A) tract of mRNAs in most mammalian cells: PABPC in the cytoplasm and PABP2/PABPN1 in the nucleus. Whereas yeast orthologs of the cytoplasmic PABP are characterized, a gene product homologous to mammalian PABP2 has not been identified in yeast. We report here the identification of a homolog of PABP2 as an arginine methyltr...
متن کاملRegulation of cyclic nucleotide-dependent protein kinase activity by histones and poly(L-arginine).
Interaction of cGMP-dependent protein kinase with histones H2A, H2B, H3, and H4, or poly(L-arginine) resulted in changes in enzyme conformation such that inactivation of cGMP binding and activation of basal catalytic activity (assayed without cGMP) occurred. Total kinase activity as determined by phosphorylation of exogenous substrates subsequently decreased, but autophosphorylation of the enzy...
متن کاملDriving DNA transposition by lentiviral protein transduction
Gene vectors derived from DNA transposable elements have become powerful molecular tools in biomedical research and are slowly moving into the clinic as carriers of therapeutic genes. Conventional uses of DNA transposon-based gene vehicles rely on the intracellular production of the transposase protein from transfected nucleic acids. The transposase mediates mobilization of the DNA transposon, ...
متن کاملAnalysis of protein arginine methylation and protein arginine-methyltransferase activity.
Posttranslational modification of proteins allows cells to adapt and react quickly to their environment beyond the boundaries set forth by genetic code. Arginine methylation, a protein modification discovered almost 30 years ago, has recently experienced a renewed interest as several new arginine methyltransferases have been identified and numerous proteins were found to be regulated by methyla...
متن کاملEffects of the cationic protein poly-L-arginine on airway epithelial cells in vitro.
BACKGROUND Allergic asthma is associated with an increased number of eosinophils in the airway wall. Eosinophils secrete cationic proteins, particularly major basic protein (MBP). AIM To investigate the effect of synthetic cationic polypeptides such as poly-L-arginine, which can mimic the effect of MBP, on airway epithelial cells. METHODS Cultured airway epithelial cells were exposed to pol...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2003
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.121.435